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To isolate and identify the constituents of a new-genus basidiomycete, Ganoderma, and investigate their pharmacological activities. The chemical constituents from the mycelium of Ganoderma atrum were isolated and purified by chromatography. The chemical constituents were identified by physico-chemical properties and spectral data. Six compounds were obtained and identified as ergosterol (I), cyclopiazonic acid (II), phthalic acid (III), N-phenyl-beta-D-glucopyranosylamine (IV), vanillic acid (V) and pyrogallic acid (VI). Compound I and II were isolated from this fungus for the first time. Compounds IV, V and VI were isolated from Ganoderma fungi for the first time. Compound I showed cytotoxicity against murine leukemia L1210 cells, while compounds II and VI displayed weak anti-inflammatory activity in the carrageenan rat paw edema assay.Q:
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